Stupid colours.

As for the color management box (the profile mismatch one,I guess), it is there for a reason: if your output is print, you'd better not disable it (why and how: http://www.gballard.net/psd/broken.html )
I suggest reading and understanding the info presented here:

http://www.computer-darkroom.com/ps8-colour/ps8_1.htm

I strongly second Pierre's suggestions, Mad::Matt.

Those two guys are regulars at the Adobe Photoshop forums, and have lots of good info on their sites. Bookmark 'em for continued study!