early site design layout

what are you using to build the site??
if you're using DW MX, then you could use layers and behaviors based on screen resolution(you'd also need a javascript to get that user information but it'd work)
or...
you could do it completely in javascript by naming the scrollbar and making it invisible UNLESS the users screen resolution is too low then it will activate the visiblity for the scrollbar, again you' would still need a javascript to get the users resolution .

OR ...
you could use a javascript to resize your page based on the users resolution, again needing the script to get that information , and have the browser reset the page size in accordance to the user resolution and eliminate the scrollbar all together.